Who's missing: Coutinho closing in on Aston Villa return from injury
Elsewhere, Nottingham Forest and Spurs continue to endure their respective injury crises but Aston Villa will be hopeful a few key players can return to action this weekend.
Take a look at who's out and who may still feature in the upcoming latest round of Premier League fixtures.
Arsenal v Southampton
Mohamed Elneny (Arsenal, Knock)
William Saliba (Arsenal, Back Injury)
Takehiro Tomiyasu (Arsenal, Knee Injury)
Juan Larios (Southampton, Muscle Injury)
Ainsley Maitland-Niles (Southampton, Loan Agreement)
Mohammed Salisu (Southampton, Unspecified Injury)
Che Adams (Southampton, Calf Injury)
Valentino Livramento (Southampton, Knee Injury)
Could return:
Oleksandr Zinchenko (Arsenal, Groin Injury)
Fulham v Leeds
Daniel James (Fulham, Loan Agreement)
Neeskens Kebano (Fulham, Achilles Tendon Injury)
Layvin Kurzawa (Fulham, Knee Injury)
Aleksandar Mitrovic (Fulham, Red Card)
Tyler Adams (Leeds, Thigh Injury)
Stuart Dallas (Leeds, Broken Leg)
Brentford v Aston Villa
Kristoffer Ajer (Brentford, Calf Injury)
Pontus Jansson (Brentford, Thigh Injury)
Keane Lewis-Potter (Brentford, Knee Injury)
Jed Steer (Aston Villa, Muscle Injury)
Could return:
Leon Bailey (Aston Villa, Thigh Injury)
Matty Cash (Aston Villa, Calf Injury)
Philippe Coutinho (Aston Villa, Thigh Injury)
Boubacar Kamara (Aston Villa, Ankle Injury)
Crystal Palace v Everton
Nathaniel Clyne (Crystal Palace, Knee Injury)
Vicente Guaita (Crystal Palace, Calf Injury)
Wilfried Zaha (Crystal Palace, Groin Injury)
Seamus Coleman (Everton, Thigh Injury)
Abdoulaye Doucoure (Everton, Red Card)
Andros Townsend (Everton, Knee Injury)
Could return:
Nathan Ferguson (Crystal Palace, Lacking Match Fitness)
Amadou Onana (Everton, Muscle Injury)
Ruben Vinagre (Everton, Calf Injury)
Leicester v Wolves
James Justin (Leicester, Knee Injury)
Ricardo Pereira (Leicester, Thigh Injury)
Jannik Vestergaard (Leicester, Calf Injury)
Chiquinho (Wolves, Knee Injury)
Sasa Kalajdzic (Wolves, Knee Injury)
Could return:
Harvey Barnes (Leicester, Thigh Injury)
Ryan Bertrand (Leicester, Knee Injury)
Jonny Evans (Leicester, Illness)
Boubacar Traore (Wolves, Muscle Injury)
Liverpool v Nottingham Forest
Stefan Bajcetic (Liverpool, (Muscle Injury)
Naby Keita (Liverpool, (Muscle Injury)
Calvin Ramsay (Liverpool, (Knee Injury)
Serge Aurier (Nottingham Forest, Knock)
Giulian Biancone (Nottingham Forest, Knee Injury)
Willy Boly (Nottingham Forest, Thigh Injury)
Dean Henderson (Nottingham Forest, Thigh Injury)
Cheikhou Kouyate (Nottingham Forest, Thigh Injury)
Omar Richards (Nottingham Forest, Calf Injury)
Chris Wood (Nottingham Forest, Thigh Injury)
Ryan Yates (Nottingham Forest, Shoulder Injury)
Could return:
Jack Colback (Nottingham Forest, Head Injury)
Gustavo Scarpa (Nottingham Forest, Knee Injury)
Bournemouth v West Ham
Ryan Fredericks (Bournemouth, Calf Injury)
Junior Stanislas (Bournemouth, Unspecified Injury)
Gianluca Scamacca (West Ham, Knee Injury)
Could return:
Hamed Junior Traore (Bournemouth, Ankle Injury)
Matias Vina (Bournemouth, Back Injury)
Newcastle v Tottenham Hotspur
Ryan Fraser (Newcastle, Calf Injury)
Emil Krafth (Newcastle, Knee Injury)
Allan Saint-Maximin (Newcastle, Hamstring Injury)
Rodrigo Bentancur (Tottenham, Knee Injury)
Yves Bissouma (Tottenham, Ankle Injury)
Ben Davies (Tottenham, Muscle Injury)
Clement Lenglet (Tottenham, Muscle Injury)
Lucas Moura (Tottenham, Red Card)
Emerson Royal (Tottenham, Knee Injury)
Ryan Sessegnon (Tottenham, Thigh Injury)
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