Wales bring uncapped O'Connor into squad for Ireland test
O'Connor has been rewarded for good form with Scarlets after Griffin succumbed to a knee injury sustained in the narrow 16-14 loss to England in their previous game.
He is one of several potential tightheads in the squad with Keiron Assiratti (26), Dillon Lewis (28) and Leon Brown (27) also possible contenders to start in Dublin.
O'Connor has yet to make a full international appearance but did tour South Africa with Wales in 2022 and played against the Barbarians in a non-cap fixture in November.
Wales have narrowly lost both Six Nations matches so far this year, also scoring 26 unanswered points in the second half at home to Scotland in an opening 27-26 loss.