Erasmus said after Saturday's 18-12 victory over New Zealand in Cape Town that took his side to the cusp of a first Rugby Championship title win since 2019, that he would split his squad in two, with a group of players staying in South Africa for the home Test with Argentina a week later.
The Springboks lead the standings with 18 points from four games, ahead of second-placed Argentina on 10, and victory will clinch the trophy for the fifth time in their history.
Grobbelaar did not play in the back-to-back wins over New Zealand but with Malcolm Marx the only other specialist hooker in the party, is likely to get a run in Argentina.
Bongi Mbonambi (hooker), Frans Malherbe (prop), Pieter-Steph du Toit (loose forward), Sacha Feinberg-Mngomezulu (fly-half), Damian de Allende (centre), Cheslin Kolbe (wing) and Willie le Roux (full-back) all remain at home to manage their workload.
"We have been open about our policy to try to give as many players in our wider squad as possible a chance to play against the top teams in the world," Erasmus said.
"We believe playing against Argentina in Santiago, where we are expecting a massive encounter in front of a hostile crowd, will serve as a great test for this group of players.
"The players we decided to rest have really done their bit this season and their bodies deserve a break, so we thought the best for them would be to enjoy a break and spend time with their families."
Erasmus has named only two centres in Lukhanyo Am and Jesse Kriel, but fly-half Handre Pollard can cover the number 12 jersey and utility back Canan Moodie the number 13.
Manie Libbok, who featured at fly-half during the Rugby World Cup in France last year but has barely had a look in since with the emergence of Feinberg-Mngomezulu, could also get a rare run in the team.
South Africa squad:
Props: Thomas du Toit, Vincent Koch, Ox Nche, Gerhard Steenekamp
Hookers: Johan Grobbelaar, Malcolm Marx
Locks: Eben Etzebeth, Nicolaas Janse van Rensburg, Salmaan Moerat, Ruan Nortje
Loose forwards: Ben-Jason Dixon, Siya Kolisi, Elrigh Louw, Kwagga Smith, Marco van Staden, Jasper Wiese
Utility forward: Jan-Hendrik Wessels
Scrum-halves: Jaden Hendrikse, Cobus Reinach, Grant Williams
Fly-halves: Manie Libbok, Handre Pollard
Centres: Lukhanyo Am, Jesse Kriel
Outside backs: Kurt-Lee Arendse, Aphelele Fassi, Makazole Mapimpi
Utility back: Canan Moodie
