Coach Rassie Erasmus has been able to call on captain Siya Kolisi at flank after he was cleared to play following a facial injury in the 31-27 victory over the All Blacks in Johannesburg last weekend.
"Siya had two options because it is a nose fracture. He could either have it set back now and be out for three weeks or have it done in two weeks, which is what he has chosen," South Africa coach Rassie Erasmus told reporters.
"We asked Siya the question if he would be half-hearted in contact because his nose is sore, but he came through training this week without any problem."
Le Roux, who replaces Aphelele Fassi, is joined in the back three by wings Canan Moodie and Cheslin Kolbe, with Kurt-Lee Arendse ruled out due to concussion.
Double World Cup-winning wing Makazole Mapimpi was not considered for selection as his wife is due to give birth.
Damian de Allende and Jesse Kriel are paired in the centres, while Pollard replaces Sacha Feinberg-Mngomezulu, who moves to the bench.
"We have a bit of a plan around the next three years, I think we have been fair to guys to give them exposure. Fassi is definitely part of that plan," Erasmus said.
Grant Williams gets to start at scrum-half with Jaden Hendrikse taking his place on the bench in a rare 5-3 split between forwards and backs from Erasmus.
Jasper Wiese remains at number eight and Pieter-Steph du Toit returns to the flank after playing lock last weekend.
Eben Etzebeth moves to within one of all-time Springboks cap record-holder Victor Matfield with his 126th appearance as he starts in the second row alongside Ruan Nortje.
Bongi Mbonambi is at hooker between props Frans Malherbe and Ox Nche.
"This match is going to be massive," said Erasmus. "New Zealand are a world-class outfit and we know that they’ll be desperate to bounce back after leading in the second half last week."
Team: 15-Willie le Roux, 14-Canan Moodie, 13-Jesse Kriel, 12-Damian de Allende, 11-Cheslin Kolbe, 10-Handre Pollard, 9-Grant Williams, 8-Jasper Wiese, 7-Pieter-Steph du Toit, 6-Siya Kolisi (captain), 5-Ruan Nortje, 4-Eben Etzebeth, 3-Frans Malherbe, 2-Bongi Mbonambi, 1-Ox Nche
Replacements: 16-Malcolm Marx, 17-Gerhard Steenekamp, 18-Vincent Koch, 19-Kwagga Smith, 20-Elrigh Louw, 21-Jaden Hendrikse, 22-Sacha Feinberg-Mngomezulu, 23-Lukhanyo Am
