Etzebeth is preparing to play in his 128th test and move one ahead of previous record holder and former second-row Victor Matfield as South Africa seek the point they need to claim the southern hemisphere championship for the fifth time.
They would have done so already had Libbok not missed a late penalty from in front of the posts during last weekend’s 29-28 defeat in Argentina that leaves the latter within five points of the Springboks in second place in the table.
Argentina must win with a try-scoring bonus point and deny South Africa any points to claim their first Rugby Championship title.
But Springbok coach Rassie Erasmus has brought back his experienced players for Saturday’s fixture after making 10 changes for the previous game.
Cheslin Kolbe returns on the wing, Damian de Allende at inside centre, Pieter-Steph du Toit and Siya Kolisi on the flank, Etzebeth starts in the second row, Frans Malherbe is at prop and Bongi Mbonambi starts at hooker.
"As a former Springbok I can attest to what a massive achievement it will be for Eben to become the most capped Springbok ever, and we want to make this a special and memorable occasion for him," Erasmus said.
"If we can win the title it would be a massive occasion for the team and Eben as an individual."
Libbok has been entrusted with the number 10 jersey despite his poor kicking record off the tee, with Handre Pollard on the bench as one of three backs along with scrum-half Cobus Reinach and centre Lukhanyo Am.
"Manie's general play is fantastic, and he brings a lot of energy and play-making abilities to the backline," Erasmus said. "He dictates play well, so we back Manie fully to do the job for us at flyhalf.
"It's not just up to him to find solutions for his goal-kicking, it is something we have to do as a team, and we are working on a plan."
Both Kolbe and starting scrum-half Jaden Hendrikse can also kick off the tee.
Team: 15-Aphelele Fassi, 14-Cheslin Kolbe, 13-Jesse Kriel, 12-Damian de Allende, 11-Kurt-Lee Arendse, 10-Manie Libbok, 9-Jaden Hendrikse, 8-Jasper Wiese, 7-Pieter-Steph du Toit, 6-Siya Kolisi (captain), 5-Ruan Nortje, 4-Eben Etzebeth, 3-Frans Malherbe, 2-Bongi Mbonambi, 1-Ox Nche
Replacements: 16-Malcolm Marx, 17-Gerhard Steenekamp, 18-Vincent Koch, 19-Elrigh Louw, 20-Kwagga Smith, 21-Cobus Reinach, 22-Handre Pollard, 23-Lukhanyo Am
