Porter, who has two caps from the summer tour of Australia, will play outside the Marcus Smith-Owen Farrell partnership, with Manu Tuilagi dropping to the bench.
Sam Simmonds will start at number eight as Billy Vunipola also moves to the replacements, while there is also a return for winger Jonny May in place of Joe Cokanasiga, who drops out of England's matchday squad.
England team:
15-Freddie Steward, 14-Jack Nowell,13-Guy Porter, 12-Owen Farrell (captain), 11-Jonny May, 10-Marcus Smith, 9-Jack van Poortvliet, 8-Sam Simmonds, 7-Tom Curry, 6-Maro Itoje, 5-Jonny Hill, 4-David Ribbans, 3-Kyle Sinckler, 2-Luke Cowan-Dickie, 1-Ellis Genge
Replacements: 16-Jamie George 17-Mako Vunipola, 18-Joe Heyes 19-Alex Coles, 20. Billy Vunipola, 21-Ben Youngs, 22-Henry Slade, 23-Manu Tuilagi
Japan make just one change
Japan coach Jamie Joseph on Thursday made only one switch at wing where Gerhard van den Heever comes in for Siosaia Fifita after the 38-31 loss in Tokyo to the All Blacks at the end of last month.
“As a team, we're very excited about going to Twickenham, we all know it's a very different and unique rugby environment,” Joseph told a news conference on Thursday.
“It’s exciting because we play them in the World Cup next year, we are up against a tier one nation and the payers are raring to go after their performance against the All Blacks.”
Japan team:
15-Ryohei Yamanaka, 14-Kotaro Matsushima, 13-Dylan Riley, 12-Ryoto Nakamura, 11-Gerhard van den Heever, 10-Takuya Yamasawa, 9-Yutaka Nagare, 8-Tevita Tatafu, 7-Kazuki Himeno, 6-Michael Leitch, 5-Jack Cornelsen, 4-Warner Dearns, 3-Jiwon Koo, 2-Atsushi Sakate (captain), 1-Keita Inagaki
Replacements: 16-Kosuke Horikoshi, 17-Craig Millar, 18-Yusuke Kizu, 19-Wimpie van der Walt, 20-Pieter Labuschagne, 21-Naoto Saito, 22-Seungsin Lee, 23-Siosaia Fifita.
