Bavuma sustained a soft tissue injury in his arm after diving for the crease while batting in South Africa’s 174-run victory in the second ODI on Friday, the same injury that kept him sidelined for a lengthy period two years ago.
Opener Reeza Hendricks will take his place in the squad for the final match in the series with South Africa holding an unassailable 2-0 lead. All-rounder Wiaan Mulder has returned home for personal reasons.
"Bavuma will return home with the rest of the squad on Tuesday and will consult a specialist. An update on the extent of his injury will be provided in due course," Cricket South Africa said in a statement on Sunday.
Bavuma is a key part of the test batting lineup and his absence for what is likely to be a challenging series in Bangladesh would be a massive blow to the side.
