Brugge top Group B after edging visitors Bayer Leverkusen 1-0 and thrashing Porto 4-0 away in two upset results at the start of the group phase.
Hoefkens said a confident approach against Atletico could deliver another positive result and move his side closer to the knockout stages.
“We have to show absolute faith. That wasn't always the case in the past," the coach told a news conference on Monday.
“You need the right mindset for this competition and we are taking steps in that direction.
If we're having a good day, we can always win, it doesn't matter who the opponent,” he said.
But he warned that Atletico, who beat Porto 2-1 in Madrid but lost 2-0 at Leverkusen, would be a major obstacle.
"Of course, we know that we will be playing one of the top European teams. Six points out of six has given us loads of confidence but Atletico are a huge threat, both at home and away. They have a lot of qualities."
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