Flanker Cane and centre David Havili (27) suffered concussions in the 39-37 win over the Wallabies in Melbourne in New Zealand's last outing and both will miss Saturday's return match in Auckland.
Lock Sam Whitelock (33) will lead the side in Cane's absence for a match which the All Blacks need to win as convincingly as possible to ensure South Africa do not pip them to the title after their final-round encounter with Argentina.
Dalton Papali'i (24) replaces Cane at openside flanker in an entirely new back row with Akira Ioane (27) in at blindside for the injured Scott Barrett (28) and Savea back at number eight after missing the Melbourne match for the birth of his third child.
As he did during the Melbourne match, Jordie Barrett (25) moves forward from fullback to replace Havili at inside centre with his brother Beauden (31) promoted from the bench to play in the number 15 shirt.
Coach Ian Foster also named Codie Taylor (31) at hooker with Samisoni Taukei'aho (25) backing up from the bench and Dane Coles (35) dropping out of the squad.
Roger Tuivasa-Sheck (29) comes onto the bench as midfield cover in place of Quinn Tupaea (23), who came on as a replacement in Melbourne but suffered a season-ending knee injury.
Wallabies lock Darcy Swain (25) was on Thursday handed a six-week ban for the dangerous cleanout which led to Tupaea's injury.
Team: 15-Beauden Barratt, 14-Will Jordan, 13-Rieko Ioane, 12-Jordie Barrett, 11-Caleb Clarke, 10-Richie Mo'unga, 9-Aaron Smith, 8-Ardie Savea, 7-Dalton Papali'i, 6-Akira Ioane, 5-Sam Whitelock (captain), 4-Brodie Retallick, 3-Tyrel Lomax, 2-Codie Taylor, 1-Ethan de Groot
Replacements: 16-Samisoni Taukei'aho, 17-Ofa Tu'ungafasi, 18-Nepo Laulala, 19-Tupou Vaa'i, 20-Hoskins Sotutu, 21-Finlay Christie, 22-Roger Tuivasa-Sheck, 23-Sevu Reece
